He overcame a crowded field of GOP hopefuls who tried to paint him as part of a broken system in Washington.
Boozman escaped the possibility of a runoff after winning the majority of votes cast in Arkansas' Republican primary on Tuesday. He defeated seven rivals for the nomination.
The state's only Republican congressman scrapped a re-election bid and decided to challenge incumbent Sen. Blanche Lincoln.
Lincoln was forced into a Democratic Party runoff by Lt. Gov. Bill Halter.
Boozman's brother Fay lost to Lincoln in 1998. He has been in the U.S. House since 1991.
(Copyright 2010 by The Associated Press. All Rights Reserved.)